Todd Macfarlan, Ph.D.
Research Associate
Email: macfarlan@salk.edu
Extension: x2019
2005 Ph.D. Cell and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
2000 B.S. Biochemistry and Molecular Biology, Penn State University, State College, PA
2005-present
Post Doctoral Study, The Salk Institute, La Jolla, CA
Samuel L. Pfaff, Ph.D., Supervisor
2001-2005
Graduate Study, University of Pennsylvania, Pennsylvania, PA
Debu Chakravarti, Ph.D., Supervisor
1998-2000
Undergraduate Study, Penn State University, State College, PA
2006-present
CIRM Fellowship
2002-2004
NRSA in Genetics
2002
Invited Short Talk, Keystone Symposia
2001
NRSA in Molecular Biology
Macfarlan TS, Gifford WD, Agarwal S, Driscoll S, Lettieri K, Wang J, Andrews SE, Franco L, Rosenfeld MG, Ren B, Pfaff SL. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev. 2011 25:594-607.
Macfarlan T, Parker JB, Nagata K, Chakravarti D.THAP7 associates with Template Activating Factor-Iβ/SET and inhibits histone acetylation to repress transcription.Mol Endocrinol. 2006 Feb; 20 (2): 335-47.
Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D. Human THAP7 is a chromatin associated, histone tail binding protein that represses transcription via recruitment of HDAC3 and NCoR.J Biol Chem. 2005 Feb 25; 280 (8): 7346-58.
Hong R, Macfarlan T, Kutney SN, Seo SB, Mukai Y, Yelin F, Pasternack GR, Chakravarti D. The identification of phosphorylation sites of pp32 and biochemical purification of a cellular pp32-kinase.Biochemistry. 2004 Aug 10;43(31):10157-65.
Kutney SN, Hong R, Macfarlan T, Chakravarti D. A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. J Biol Chem. 2004 Jul 16;279(29):30850-5.
Li F, Macfarlan T, Pittman RN, Chakravarti D. Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. J Biol Chem. 2002 Nov 22;277(47):45004-12.
Seo SB, Macfarlan T, McNamara P, Hong R, Mukai Y, Heo S, Chakravarti D. Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. J Biol Chem. 2002 Apr 19;277(16):14005-10.
Pohlmann S, Leslie GJ, Edwards TG, Macfarlan T, Reeves JD, Hiebenthal-Millow K, Kirchhoff F, Baribaud F, Doms RW. DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions.J Virol. 2001 Nov;75(21):10523-6.
Baribaud F, Pohlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, Doms RW. Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.J Virol. 2001 Nov;75(21):10281-9.
ABCAM Stem Cell Conference, December 2006
ABCAM Chromatin Conference, Fall 2004
Keysone Symposia, Nuclear Hormone Receptors, Spring 2003
Keystone Symposia, Chromatin, invited short talk, Spring 2002