Dario Bonanomi, Ph.D.
Research Associate
Email: bonanomi@salk.edu
Extension: x2020
2006 Ph.D. Molecular and Cellular Biology, The Open University (London, UK)/San Raffaele Scientific Institute (Milan, Italy) joint graduate program.
Thesis Title: "Molecular mechanisms of protein sorting in the synaptic vesicle life cycle"
Dr. Flavia Valtorta, Thesis Advisor
2000 Degree in Biology (Molecular Biology), University of Milan, School of Biogical Sciences, Italy
2006-present
Research Associate, The Salk Institute, La Jolla, CA
Samuel L. Pfaff, Ph.D., Supervisor
2001-2002
Trainee, DIBIT-San Raffaele Scientific Institute
Dr. Flavia Valtorta, Supervisor
1999-2000
Undergraduate student, DIBIT-San Raffaele Scientific Institute
Dr. Flavia Valtorta, Supervisor
2005-2006
Fellowship for postdoctoral training from the Italian Ministry of University and Scientific Research
2001
Fellowship from the Italian Foundation for Multiple Sclerosis
2000
National graduation prize, University of Trieste, Italy
Graduated with Honors, B.S. Biology, University of Milan, Italy
1997-1999
Scholarship support from the Cariplo Foundation, Italy
Bonanomi D, Chivatakarn O, Bai G, Abdesselem H, Lettieri K, Marquardt T, Pierchala BA, Pfaff SL. Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Cell. 2012 Feb 3;148(3):568-82.
Macfarlan TS, Gifford WD, Driscoll S, Lettieri K, Rowe HM, Bonanomi D, Firth A, Singer O, Trono D, Pfaff SL. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature. 2012 Jul 5;487(7405):57-63.
Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL. Presenilin-dependent receptor processing is required for axon guidance. Cell. 2011 Jan 7;144(1):106-18.
Badaloni A, Bonanomi D, Albieri I, Givogri I, Bongarzone E, Valtorta F, Consalez GG.Transgenic mice expressing a dual, CRE-inducible reporter for the analysis of axon guidance and synaptogenesis. Genesis. 2007, 45:405-12.
Bonanomi D*, Rusconi L*, Colombo CA, Benfenati F, Valtorta F. Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin2/VAMP2. Biochem J. 2007, 404:525-34.
Menegon A, Bonanomi D, Albertinazzi C, Lotti F, Ferrari G, Kao HT, Benfenati F, Baldelli P, Valtorta F. Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity. J Neurosci. 2006, 26:11670-81.
Bonanomi D, Benfenati F, Valtorta F. Protein sorting in the synaptic vesicle life cycle. Prog Neurobiol. 2006, 80:177-217. Review
Bonanomi D, Menegon A, Miccio A, Ferrari G, Corradi A, Kao HT, Benfenati F, ValtortaF. Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons. J Neurosci. 2005, 25:7299-308.
Bonanomi D, Pennuto M, Rigoni M, Rossetto O, Montecucco C, Valtorta F. Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2. Mol Pharmacol. 2005, 67:1901-8.
Valtorta F, Pennuto M, Bonanomi D, Benfenati F. Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis? Bioessays. 2004, 26:445-53. Review
Pennuto M*, Bonanomi D*, Benfenati F, Valtorta F. Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles. Mol Biol Cell. 2003, 14:4909-19.
Contestabile A*, Bonanomi D*, Burgaya F, Girault JA, Valtorta F. Localization of focal adhesion kinase isoforms in cells of the central nervous system. Int J Dev Neurosci. 2003, 21:83-93. (* denotes equal contribution)
D. Bonanomi, F. Valtorta (2006). Focal adhesion kinase in neuritogenesis. In Intracellular Mechanisms for Neuritogenesis. De Curtis. I., ed. (Springer, NY).
F. Valtorta, D. Bonanomi (2004). Post-translational modifications. In Farmacologia Generale e Molecolare 3rd Edition, Clementi F., Fumagalli G., eds. (UTET, Torino, Italy), pp. 188-198.
D. Bonanomi, F. Valtorta (2004). Focal adhesion kinase in cell motility and neurite extension. Recent Research Developments in Biochemistry, Research Signpost (Kerala, India) 5:115-128.