Publications

Uchida, T., Takamiya, M., Takahashi, M., Miyashita, H., Ikeda, H., Terada, T., Matsuo, Y., Shirouzu, M., Yokoyama, S., Fujimori, F., and Hunter, T. 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem. Biol. 10:15-24.

Xia, Y., Pao, G. M., Chen, H.-W., Verma, I. M., and Hunter, T. 2003. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J. Biol. Chem. 278:5255-5263.

Verdecia, M. A., Joazeiro, C. A. P., Wells, N. J., Ferrer, J.-L., Bowman, M. E., Hunter, T., and Noel, J. P. 2003. Conformational flexibility underlies ubiquitin ligation by the WWP1 HECT domain E3 ligase. Mol. Cell 11:249-259.

Shah, O. J., Ghosh, S., and Hunter, T. 2003. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr,Pro phosphorylation of consensus and non-consensus sites by Cdc2. J. Biol. Chem.278:16433-16442.

Woodring, P. J., Hunter, T., and Wang, J. Y. J. 2003. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J. Cell Sci. 116:2613-2126.

Sonnenburg, E. D., Bilwes, A. M., Hunter, T., and Noel, J. P. 2003. Structure of the membrane-distal phosphatase domain of RPTPareveals interdomain flexibility and an SH2 domain interaction region. Biochemistry 42:7904-7414.

Liou, Y.-C., Sun, A., Ryo, A., Zhou, X. Z., Yu, Z.-X., Huang, H.-K., Uchida, T., Bronson, R., Bing, G., Li, X., Hunter, T. and Lu, K. P. 2003. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424:556-561.

Lorén, C. E., Englund, C., Grabbe, C., Hallberg, B., Hunter, T.,and Palmer, R. H. 2003. A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Reports 4:781-786.

Lu, Z., Ghosh, S., Wang, Z., and Hunter, T. 2003. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of b-catenin and enhanced tumor cell invasion. Cancer Cell 4:499-515.

Olbina, G. and Eckhart, W. 2003. Mutations in the second extracellular region of connexin 43
prevent localization to the plasma membrane, but do not affect its ability to suppress cell
growth. Mol. Cancer Res. 1:690-700.

Eckhart/Hunter Lab Publications
2003 2004 2005 2006 2007 2008 2009 2010	All laboratory publications are listed under the year they were published. Click on the year and all publications from that year will be listed in chronological order.
2003	Uchida, T., Takamiya, M., Takahashi, M., Miyashita, H., Ikeda, H., Terada, T., Matsuo, Y., Shirouzu, M., Yokoyama, S., Fujimori, F., and Hunter, T. 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem. Biol. 10:15-24. Xia, Y., Pao, G. M., Chen, H.-W., Verma, I. M., and Hunter, T. 2003. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J. Biol. Chem. 278:5255-5263. Verdecia, M. A., Joazeiro, C. A. P., Wells, N. J., Ferrer, J.-L., Bowman, M. E., Hunter, T., and Noel, J. P. 2003. Conformational flexibility underlies ubiquitin ligation by the WWP1 HECT domain E3 ligase. Mol. Cell 11:249-259. Shah, O. J., Ghosh, S., and Hunter, T. 2003. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr,Pro phosphorylation of consensus and non-consensus sites by Cdc2. J. Biol. Chem.278:16433-16442. Woodring, P. J., Hunter, T., and Wang, J. Y. J. 2003. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J. Cell Sci. 116:2613-2126. Sonnenburg, E. D., Bilwes, A. M., Hunter, T., and Noel, J. P. 2003. Structure of the membrane-distal phosphatase domain of RPTPareveals interdomain flexibility and an SH2 domain interaction region. Biochemistry 42:7904-7414. Liou, Y.-C., Sun, A., Ryo, A., Zhou, X. Z., Yu, Z.-X., Huang, H.-K., Uchida, T., Bronson, R., Bing, G., Li, X., Hunter, T. and Lu, K. P. 2003. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424:556-561. Lorén, C. E., Englund, C., Grabbe, C., Hallberg, B., Hunter, T.,and Palmer, R. H. 2003. A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Reports 4:781-786. Lu, Z., Ghosh, S., Wang, Z., and Hunter, T. 2003. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of b-catenin and enhanced tumor cell invasion. Cancer Cell 4:499-515. Olbina, G. and Eckhart, W. 2003. Mutations in the second extracellular region of connexin 43 prevent localization to the plasma membrane, but do not affect its ability to suppress cell growth. Mol. Cancer Res. 1:690-700.
2004	Hunter, T., and Eckhart, W. 2004. The discovery of tyrosine phosphorylation: it’s all in the buffer! Cell S116:S35-S39. Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., and Osada, H. 2004.M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFb-TrCP.Proc. Natl. Acad. Sci. USA 101:4419-4424. Shah, O. J., and Hunter, T. 2004. Critical role of T-Loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the Tuberous Sclerosis Complex. J. Biol. Chem. 279:20816-20823. Woodring, P. J., Meisenhelder, J., Johnson, S. A., Zhou, G-L., Field, J., Shah, K.,Bladt, F., Pawson, T., Niki, M., Pandolfi, P. P., Wang, J. Y. J., and Hunter, T. 2004. c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J. Cell Biol. 165:493-503. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., and Mustelin, T. 2004. Protein tyrosine phosphatases in the human genome. Cell 117:699-711. Caenepeel, S., Charydczak, G., Sudarsanam, S., Hunter, T., and Manning, G. 2004. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc. Natl. Acad. Sci. USA 101:11707-11712. Shah, O. J., Wang, Z., and Hunter, T. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14:1650-1656. Grabbe, C., Zervas, C. G., Hunter, T., Brown, N. H., and Palmer, R. H. 2004. Focal adhesion kinase is not required for integrin function or viability in Drosophila. Development 131:5795-5805.
2005	Johnson, S. A., and Hunter, T. 2005. Kinomics: methods for deciphering the kinome. Nature Meth. 2:17-25. Kamada, S., Kikkawa, U., Tsujimoto, Y., and Hunter, T. 2005. Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J. Biol. Chem. 280:857-860. Woodring, P. J., Hunter, T., and Wang, J. Y. J. 2005. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J. Biol. Chem. 280:10318-10325. Marquardt, T., Shirasaki, R., Ghosh, S., Andrews, S. E., Carter, N., Hunter, T., and Pfaff, S. L. 2005. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 121:127-139. Takagi, Y., Masuda, C. A., Chang, W.-H., Komori, H., Wang, D., Hunter, T., Joazeiro, C. A. P., and Kornberg, R. D. 2005. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol. Cell 18:237-243. You, Z., Chahwan, C., Bailis, J., Hunter, T., and Russell, P. 2005. ATM activation and its recruitment to damaged DNA require binding to the C-terminus of Nbs1. Mol. Cell. Biol. 25:5363-5379. Wang, X., Li, X., Meisenhelder, J., Hunter, T., Yoshida, S., Asami, T., and Chory, J. 2005. Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev. Cell 8:855-865. Watanabe, N., Arai, H., Iwasaki, J.-I., Shiina, M., Ogata, K., Hunter, T., and Osada, H. 2005. Cyclin-dependent kinase (CDK) phosphorylation destabilizes Wee1A via multiple pathways. Proc. Natl. Acad. Sci. USA 102:11663-11668. Huang, H.-K., Bailis, J. M., Gomez, E. B., Leverson, J. D., Forsburg, S. L., and Hunter, T. 2005. Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. Mol. Cell. Biol. 25:9000-9015. Kamada, S., Kikkawa, U., Tsujimoto, Y., and Hunter, T. 2005. A-kinase anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase-3 through an enzyme-substrate like association. Mol. Cell. Biol. 25:9469-9477. Hunter, T., and Schulman, H. 2005. CaMKII structure – an elegant design. Cell 123:765-767.
2006	Yanochko, G. M. and W. Eckhart (2006). Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells. Breast Cancer Res 8 R18. Ghosh, S., Tergaonkar, V., Rothlin, C.V., Correa, R.G., Bottero, V., Bist, P., Verma, I.M., and Hunter, T. (2006). Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell 10, 215-226. Petersen, P., Chou, D.M., You, Z., Hunter, T., Walter, J.C., and Walter, G. (2006). Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol 26, 1997-2011. Shah, O.J., and Hunter, T. (2006). Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol 26, 6425-6434. Wang, Z., Qi, C., Krones, A., Woodring, P., Zhu, X., Reddy, J.K., Evans, R.M., Rosenfeld, M.G., and Hunter, T. (2006). Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab 3, 111-122. *Wolff, S., Ma, H., Burch, D., Maciel, G.A., Hunter, T., and Dillin, A. (2006). SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124, 1039-1053.
2007	Johnson, S.A., You, Z., and Hunter, T. (2007). Monitoring ATM kinase activity in living cells. DNA Repair 6, 1277-1284. Sun, H., Leverson, J.D., and Hunter, T. (2007). Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J 26, 4102-4112. Xia, Y., Wang, J., Liu, T.J., Yung, W.K., Hunter, T., and Lu, Z. (2007). c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell 25, 219-232. Xia, Y., Wang, J., Xu, S., Johnson, G.L., Hunter, T., and Lu, Z. (2007). MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 27, 510-517. You, Z., Bailis, J.M., Johnson, S.A., Dilworth, S.M., and Hunter, T. (2007). Rapid activation of ATM on DNA flanking double-strand breaks. Nat Cell Biol 9, 1311-1318. **Zhang, Y., Daum, S., Wildemann, D., Zhou, X.Z., Verdecia, M.A., Bowman, M.E., Lucke, C., Hunter, T., Lu, K.P., Fischer, G., et al. (2007). Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol 2, 320-328. Pearson, G.W, and Hunter, T. (2007). Real-time imaging reveals that non-invasive mammary epithelial acini can contain motile cells. J. Cell Biol. 179, 1555-1567.
2008	Ghosh, S., Marquardt, T., Thaler, J. P., Carter, N., Andrews, S. E., Pfaff, S. L., and Hunter, T. (2008). Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. Proc. Natl. Acad. Sci. USA 105, 335-340. Bailis, J.M., Luche, D.D., Hunter, T., and Forsburg, S.L. (2008). MCM proteins interact with checkpoint and recombination proteins to promote S phase genome stability. Mol. Cell. Biol. in press. Hashimoto, T., Yamauchi, L., Hunter, T., Kikkawa, U., and Kamada, S. 2008. Possible involvement of caspase-7 in cell cycle progression at mitosis. Genes Cells 13: 609-621. Hunter, T., and Sun, H. 2008. Crosstalk between the SUMO and ubiquitin pathways. In Ernst Schering Foundation Symposium on "The Ubiquitin System in Health and Disease", pp. 1-16.
2009	Copp, J., Manning, G., and Hunter, T. 2009. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 69: 1821-1827. Smith, J. J., Putta, S. , Zhu, W., Pao, G. M., Verma, I. M., Hunter, T. , Bryant, S. V., Gardiner, D. M., Harkins, T. T., and Voss, S. R. 2009. Genic regions of a large salamander genome contain long introns and novel genes. BMC Genomics 10: 19. Monaghan, J. R., Epp, L. G., Putta, S., Page, R. B., Walker, J. A. , Beachy, C. K., Zhu, W., Pao, G. M., Verma, I. M., Hunter, T. , Bryant, S. V., Gardiner, D. M., Harkins, T. T., and Voss, S. R. 2009. Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. BMC Biol. 7: 1. Lu, Z., and Hunter, T. 2009. Degradation of activated protein kinases by ubiquitination. Annu. Rev. Biochem. 78: 435-475. Carrano, A. C., Liu, Z., Dillin, A., and Hunter, T. 2009. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460: 396-399 . Joazeiro, C. A. P., and Hunter, T. 2009. RING finger proteins as E3 ubiquitin ligases. In Protein Discovery Technologies: Principles (R. Pasqualini and W. Arap, eds), pp.203-213, CRC Press. Pearson, G. W., and Hunter, T. 2009. PI-3 kinase activity is necessary for ERK1/2 induced disruption of mammary epithelial architecture. Breast Cancer Res. 11: R29 . Hunter, T. 2009. Tyrosine phosphorylation: thirty years and counting. Curr. Opin. Cell Biol. 21: 140-146. Zhang. Y.-W., Brognard, J., Coughlin, C., You, Z., Dolled-Filhart, M., Aslanian, A., Manning, G., Abraham, R. T., and Hunter, T. 2009. The F-box protein Fbx6 regulates stability of Chk1 and cellular sensitivity to replication stress. Mol. Cell 35: 442-453. Sun, H., and Hunter, T. 2009. Crosstalk between the ubiquitin and SUMO pathways. In The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology (M. Di Napoli and C. Wojcik, eds), Nova Publishers, in press. Malumbres, M., Harlow, E., Hunt, T., Hunter, T., Lahti, J. M., Manning, G., Morgan, D. O., Tsai, L.-H., and Wolgemuth, D. J. 2009. Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11: 1275-1276. Manning, G., and Hunter. T. 2009. Eukaryotic kinomes: genomics and evolution of protein kinases. In Handbook of Cell Signaling, Second Edition (R.A. Bradshaw and E.A. Dennis, eds), Vol. 1 , pp. 393-397, Elsevier Press. You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y. W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., and Hunter, T. 2009. CtIP links DNA double-strand break sensing and resection. Mol. Cell 36: 954-969.
2010	Hunter, T, and Marais, R. 2010. Genetic and cellular mechanisms of oncogenesis: Editorial overview. Curr. Opin. Genet. Develop. 20: 1-3. López-Otín , C., and Hunter, T. 2010. The regulatory crosstalk between kinases and proteases in cancer. Nat. Rev. Cancer 10: 278-292. Lu, Z., and Hunter, T. 2010. Ubiquitylation and proteasomal degradation of the p21 Cip1 , p27 Kip1 , and p57 Kip2 CDK inhibitors. Cell Cycle 9: 2400-2411. Liew, C. W., Sun, H., Hunter, T., and Day, C. L. 2010. RING domain dimerization is essential for RNF4 function. Biochem. J. Epub Aug 3, 2010. Yoon, Y.-S., Lee, M.-W., Ryu,D., Kim, J. H., Ma, M., Seo, W.-Y., Kim, Y.-N., Kim, S. S., Lee, C. H., Hunter, T., Choi, C. S., Montminy, M., and Koo, S.-H. 2010. SMEK/PP4C regulates hepatic glucose production by controlling CRTC2 phosphorylation. Proc. Natl. Acad. Sci. USA, in press. Wang, Z., Shah, O. J., and Hunter, T. 2010. The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. submitted.
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